Maternal Mthfd1 disruption impairs fetal growth but does not cause neural tube defects in mice
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چکیده
منابع مشابه
Maternal Mthfd1 disruption impairs fetal growth but does not cause neural tube defects in mice.
BACKGROUND MTHFD1 encodes C1-tetrahydrofolate synthase, which is a folate-dependent enzyme that catalyzes the formation and interconversion of folate-activated one-carbon groups for nucleotide biosynthesis and cellular methylation. A polymorphism in MTHFD1 (1958G→A) impairs enzymatic activity and is associated with increased risk of adverse pregnancy outcomes, but the mechanisms are unknown. ...
متن کاملAssociation between MTHFD1 G1958A Polymorphism and Neural Tube Defects Susceptibility: A Meta-Analysis
OBJECTIVES The methylenetetrahydrofolate dehydrogenase (MTHFD1) gene, as one of the key genes involved in the folate pathway, has been reported to play a critical role in the pathogenesis of neural tube defects (NTDs). However, the results of published studies are contradictory and inconclusive. Thus, this meta-analysis aimed to evaluate the effect of the common polymorphism in the MTHFD1 gene,...
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ژورنال
عنوان ژورنال: The American Journal of Clinical Nutrition
سال: 2012
ISSN: 0002-9165,1938-3207
DOI: 10.3945/ajcn.111.030783